Sigma Aldrich Library of Rare Chemicals

Sigma-Aldrich is a leading Life Science (75%) and High Technology (25%) company with $1.2 billion in annual sales. Our biochemical and organic chemical products and kits are used in scientific and genomic research, biotechnology, pharmaceutical development, the diagnosis of disease and chemical manufacturing. We have customers in life science companies, university and government institutions, non-profit organizations, hospitals and in industry. Over one million scientists and technologists use our products. Sigma-Aldrich operates in 34 countries and has 6,000 employees providing excellent service worldwide.

Contact information:

Country:	United States
Telephone number:	1-800-325-3010
Web page:	http://www.sigmaaldrich.com/

Products:

LOPAC1280™
Description	Accelerate your drug discovery process by validating your assay with proven pharmacologically-active compounds. Improve screening efficiency with the newly expanded version of the Sigma-RBI Library of Pharmacologically Active Compounds. Like its predecessor (LOPAC640™), LOPAC1280™ allows you to validate your high throughput screening assays with high purity, small organic ligands with well documented pharmacological activities. The addition of compounds in areas such as apoptosis and phosphorylation broaden the application range of LOPAC1280™ to assays dealing with the hottest areas of Cell Signaling & Neuroscience research. Save time and money by reducing the number of false leads from your screen. Guide secondary screening of larger, more diverse libraries by using compounds with pharmaceuticallyrelevant structures. Explore the activity of well-characterized compounds directed at orphan receptors.
Advanced info (url)	http://www.bioscreening.com/index/LOPAC.php
MyriaScreen Diversity Collection
Description	MyriaScreen was created by combining medicinal chemistry expertise and decades of experience in compound acquisition from diverse sources. TimTec’s proprietary software was used to filter a pool of over 300,000 TimTec and Sigma-Aldrich compounds on the basis of diversity. Additional filters were set to consider MW (>225 and <600), cLogP, H-acceptor, H-donors, and rotatable bonds. Medicinal chemistry specialists refined the selection with great personal attention to remove compounds that were overly represented or not well suited for medicinal chemistry follow-up. MyriaScreen is rich in chemotypes and a valuable source of screening compounds for lead discovery.
Advanced info (url)	http://www.bioscreening.com/index/MyriaScreen.php