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Bio Expo Online
Compound LibrariesDevelopments in Focused Kinase Libraries - Chemical libraries have long been a mainstay in the search for new pharmaceutical compounds, and they have been created using many different paradigms. Vast diverse collections of unique compounds have been screened at high throughput to find appropriate effects on target proteins. Such large libraries continue to be used for drug discovery, but screening smaller, [...]
Computational Method Points To New Uses, Unexpected Side Effects Of Already Existing Drugs - Scientists at the University of North Carolina at Chapel Hill School of Medicine and the University of California, San Francisco have developed and experimentally tested a technique to predict new target diseases for existing drugs.
The researchers developed a computational method that compares how similar the structures of all known drugs are to the naturally occurring [...]
Trophos launches the new generation of its fast plate imaging instrument, the Plate RUNNER HD - Marseille, FRANCE, 2009 September 29 - Trophos SA, a clinical stage pharmaceutical company developing innovative therapeutics for indications with under-served needs in neurology and cardiology, announced today the launch of the new generation of its fluorescence fast plate imaging system, the Plate RUNNER HD(R).
Trophos originally developed the Plate RUNNER HD(R) to speed up its own [...]
Zelinsky Institute Inc. announced collaboration with ART-CHEM - Zelinsky Institute Inc. (Newark, DE, August 2009) - Zelinsky Institute Inc. expands its partnership and supplier network with the announcement of collaboration with one of the premier fine chemistry companies - ART-CHEM, which originated from Moscow, Russia, and has started its operations in Berlin, Germany, in 2005. ART-CHEM specializes in synthesis of highly diverse [...]
Sirona Biochem Says SGLT Test Results Confirm Key ‘Breakthrough’ - Sirona Biochem Corp. (TSX-V: SBM), an emerging biotech company focused on diabetes and obesity, says results of testing its unique SGLT inhibitor molecules demonstrate a key breakthrough milestone for Sirona Biochem.
Sirona Biochem CEO, Dr. Howard Verrico, said, “There are two vital steps in the early stage of drug testing: validation of concept i.e. a molecule [...]
Agilux Laboratories Hires New Associate Director to Lead In Vitro ADMET Services Division - - Adrian Sheldon, Ph.D., Positions Contract Research Organization for Growth -
WORCESTER, Mass.--(Business Wire)--
Agilux Laboratories, Inc., a Contract Research Organization (CRO) that provides
bioanalytical and in vitro Absorption Distribution Metabolism Excretion
Toxicology (ADMET) services for the biotechnology and pharmaceutical industries,
has appointed Dr. Adrian Sheldon as associate director of In Vitro ADMET
Services. In this role, Dr. Sheldon will build [...]
Bayer CropScience invests EUR 4.9 million in compound logistics - 7 Sep 2009 , Monheim : Bayer CropScience has invested EUR 4.9 million in the expansion of the compound logistics at its Monheim site. It has one of the most modern facilities in the world for storing chemical compounds. The company’s scientists use the 2.2 million or so substances currently in the collection to search for [...]
Baylor researchers find fat cell blocker - The guilt-free double Whopper experience is inching closer.
A small molecule that turns off the genes responsible for making fat cells has been discovered by a team of Baylor College of Medicine and Japanese researchers.
Dubbed “fatostatin,” the molecule blocks a protein in the cell that starts the cascade of events that turns on the 63 genes [...]
Researchers develop screening test for cells that activate immune system - UT Southwestern Medical Center researchers are the first to design a large-scale, cell-based screening method that identifies which compounds activate immune-return cells that hold compact for prospective cancer-fighting vaccines.
The new screening technique can scan thousands and even millions of compounds to identify those that activate dendritic cells, which are on constant recon patrol throughout the [...]
TimTec Expands Partnership With Collaborative Drug Discovery Through Publishing Three Additional Libraries on CDD’s Free Public Access Database - Last October, TimTec and Collaborative Drug Discovery (CDD) established a collaboration in which CDD’s web-based data management system would host two TimTec Natural Products libraries on their free community Public Access site. Through this partnership, researchers would be able to register for a free account with CDD allowing them to chemically mine the contents of these TimTec [...]
3rd International Symposium on Advances in Synthetic and Medicinal Chemistry - Kiev, Ukraine, August 23 - 27, 2009
ASMC09 in Kiev is being prepared by EFMC (European Federation for Medicinal Chemistry) and ChemBridge Corporation, in the series of events which started with ASCMC04 Moscow followed by ASMC07 St. Petersburg.
Prof. Erick Carreira, ETH Zurich, Switzerland and Dr Scott Biller, Novartis Institutes for BioMedical Research, Cambridge, USA, have kindly [...]
Plexxikon Receives Key Patents on Novel Compounds for Multiple Programs - BERKELEY, Calif.–(BUSINESS WIRE)–Plexxikon Inc. today announced the issuance of key composition-of-matter patents covering novel compounds discovered through the company’s Scaffold-Based Drug Discovery™ platform. Plexxikon’s pipeline of preclinical and clinical stage product opportunities currently span [...]
Salk Forms Stem Cell Partnership With Sanofi-Aventis - The Salk Institute says it has formed a new stem cell research partnership with Sanofi-Aventis, the international pharmaceutical giant based in Paris. Financial terms of the five-year alliance were not disclosed, and some details of the deal remain to be worked out, Salk spokesman Mauricio Minotta told me this afternoon.
The Sanofi-Aventis regenerative medicine program will [...]
Thermo Fisher Scientific Accelerates Drug Discovery Process With New Maybridge Quick2Lead™ Compound Kits - Thermo Fisher Scientific, the world leader in serving science, announced recently that it has introduced a novel tool to accelerate hit-to-lead programmes in the drug discovery process. Its Maybridge Quick2Lead™ Compound Kits are designed to save time and money by enabling rapid compound library synthesis around bioactive “hits” emerging from screening assays. The kits are [...]
Conference focuses on potential new drugs for malaria, leishmaniasis, and trypanosomiasis - A meeting in Colorado, USA has brought together chemists, biologists, pharmacologists, and clinicians in an attempt accelerate the discovery of new drugs for diseases caused by protozoan parasites. These include some of the major infectious diseases of poverty – malaria, leishmaniasis, human African trypanosomiasis and Chagas’ disease.
The organizers of the meeting, “Drug Discovery for Protozoan [...]
EPA Presents Initial Results from Caliper Life Sciences’ ToxCast Screening Effort - HOPKINTON, Mass., March 19 /PRNewswire-FirstCall/ — Caliper Life Sciences, Inc. (NASDAQ: CALP) , a leading provider of tools and services for drug discovery and life sciences research, today announced that the United States Environmental Protection Agency (EPA) presented initial analyses of Phase I data generated by Caliper Discovery Alliances and Services (CDAS) under the EPA’s [...]
Ligand Pharmaceuticals Inc. (LGND) Enters into Screening Agreement with Trevena - SAN DIEGO–(BUSINESS WIRE)–Ligand Pharmaceuticals Incorporated (NASDAQ:LGND - News) and Trevena Inc. today announced the initiation of a joint research and license alliance to screen targets using Trevena’s novel biological platform against Ligand’s combinatorial library of compounds, to identify active compounds with potential for development as novel G-protein coupled receptor (GPCR) therapeutics.
Under the terms of the [...]
ZINC Database - emolecule repository - What is ZINC? It is a free database of millions of commercially-available compounds for virtual screening in ready-to-dock format.
Why is it needed? Compounds that are available today can become unavailable in six months because of unavailability of the underlying reagents. For most vendors, the list of available compounds is significantly smaller than the list of [...]
Galapagos and Merck Serono Enter New Collaboration Agreements
Green protein inhibits Alheimer’s, CSIRO scientists find
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